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Chroniques génomiques : Myriad Genetics L’arme du secret
(Éditions EDK/Groupe EDP Sciences, 2013)
Chroniques génomiques : Snip et histoire familiale : le match !
(Éditions EDK/Groupe EDP Sciences, 2013)
Chroniques génomiques : Épigénétique et résilience
(Éditions EDK/Groupe EDP Sciences, 2013)
The likelihood of adult psychiatric problems is increased by childhood trauma, particularly so in carriers of certain alleles of certain genes. I discuss here a recent paper that sheds light on the mechanism of this effect, ...
Bébés CRISPR : Anatomie d’une transgression
(EDP Sciences, 2019)
Analysing the data recently presented by Jiankui He and assuming that it is authentic shows that the goal of abolishing the expression of CCR5 may have been reached for one of the resulting twins, although this remains to ...
Chroniques génomiques - Couleur de la peau chez l’homme : de nouvelles surprises
(EDP Sciences, 2019)
Careful GWAS analysis of a group of mixed-ancestry Latino-American individuals
reveals the role of a new “light” variant of the MSFD12 gene
which appears to originate in some of the ...
Chroniques génomiques - Modification ciblée du génome : une nouvelle approche prometteuse
(Éditions EDK, Groupe EDP Sciences, 2017)
A new approach, based on the use of peptide nucleic acid molecules to form triple helices and promote locus-specific recombination, demonstrates potential for in vivo gene correction at clinically significant levels and ...
Chroniques génomiques - Synthétique, vous avez dit « Synthétique » ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The synthesis of a minimal bacterial genome comprising only 473 genes is an impressive achievement, yet it is only a step towards a really synthetic genome based on first principles: this set of genes was derived from a ...
Chroniques génomiques - Actualités du séquençage d’ADN
(EDP Sciences, 2019)
The planned acquisition of Pacific Biosciences by Illumina could signal a big change in the DNA sequencing landscape, and provides the incentive for an update on a field that still has a number of players and could be ...
Chroniques génomiques - Hétérogénéité des tumeurs : l’apport du séquençage sur cellules individuelles
(Éditions EDK, Groupe EDP Sciences, 2014)
The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern ...
Chroniques génomiques - Slide-seq : L'analyse d'expression à haute résolution spatiale
(EDP Sciences, 2019)
A newly developed technique allows the analysis of gene expression within tissues at near-cellular resolution. This opens a whole range of applications and will be a major ingredient of future studies.