Recherche
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Analysis of the association between CDH2 gene polymorphism and osteoarthritis risk
(EDP Sciences, 2018)
Objective: to define the cadherin 2 (CDH2) gene polymorphism in Chinese osteoarthritis and control populations and to explore the correlation between CDH2 gene polymorphism and the risk of osteoarthritis. Method: a total ...
JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways
(EDP Sciences, 2018)
Melanoma is considered as one of the most potentially fatal and aggressive malignancies. Due to the limited efficacy or drug resistance of the current targeted therapies of melanoma, developing new therapeutic drugs against ...
Bone and dental abnormalities as first signs of familial Gardner’s syndrome in a Chinese family: a literature review and a case report
(EDP Sciences, 2018)
Gardner’s syndrome (GS) is an autosomal dominant disease characterized by the presence of familial adenomatous polyposis (FAP) as well as extraintestinal manifestations such as osteomas, dental anomalies, epidermoid cysts ...
Gastric carcinoma with a gastrointestinal stromal tumor : A case report and literature review
(EDP Sciences, 2018)
Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was ...
Relationship between depression and blood cytokine levels in lung cancer patients
(EDP Sciences, 2018)
Objective: To study the correlation between depression and blood cytokine levels in lung cancer patients. Methods: 92 patients with advanced lung cancer were evaluated for depression using the scoring index of depression ...
Computational QSAR model combined molecular descriptors and fingerprints to predict HDAC1 inhibitors
(EDP Sciences, 2018)
The dynamic balance between acetylation and deacetylation of histones plays a crucial role in the epigenetic regulation of gene expression. It is equilibrated by two families of enzymes: histone acetyltransferases and ...
Diagnostic efficacy of serum procalcitonin, C-reactive protein concentration and clinical pulmonary infection score in Ventilator-Associated Pneumonia
(EDP Sciences, 2018)
Objective: The aim of this study was to evaluate the diagnostic efficacy of serum procalcitonin (PCT), c-reactive protein (CRP) concentration and clinical pulmonary infection score(CPIS) in ventilator-associated pneumonia(VAP). ...
Complement protein C5a enhances the β-amyloid-induced neuro-inflammatory response in microglia in Alzheimer’s disease
(EDP Sciences, 2018)
Objective: The dysregulation of neuro-inflammation is one of the attributes of the pathogenesis of Alzheimer’s disease (AD). Over-expression of complement proteins co-localizes with neurofibrillary tangles, thereby indicating ...
Laparoscopic combined with hysteroscopic repair or operative hysteroscopy in the treatment of symptomatic cesarean-induced diverticulum
(EDP Sciences, 2018)
Objective: The postmenstrual bleeding with cesarean-induced diverticulum is a bothersome symptom and can be confused with other abnormal-uterine bleeding disease. The aim of the present study was to evaluate the efficacy ...
Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway
(EDP Sciences, 2018)
Malignant melanoma, one of the most aggressive skin cancers, has a very high mortality rate. Currently, the number of drugs to treat melanoma is low. Although new immunotherapeutic approaches based on the use of antibodies ...