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Voici les éléments 41-50 de 167
Chroniques génomiques - Modification ciblée du génome : une nouvelle approche prometteuse
(Éditions EDK, Groupe EDP Sciences, 2017)
A new approach, based on the use of peptide nucleic acid molecules to form triple helices and promote locus-specific recombination, demonstrates potential for in vivo gene correction at clinically significant levels and ...
Chroniques génomiques - Synthétique, vous avez dit « Synthétique » ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The synthesis of a minimal bacterial genome comprising only 473 genes is an impressive achievement, yet it is only a step towards a really synthetic genome based on first principles: this set of genes was derived from a ...
Chroniques génomiques - Actualités du séquençage d’ADN
(EDP Sciences, 2019)
The planned acquisition of Pacific Biosciences by Illumina could signal a big change in the DNA sequencing landscape, and provides the incentive for an update on a field that still has a number of players and could be ...
Chroniques génomiques - Hétérogénéité des tumeurs : l’apport du séquençage sur cellules individuelles
(Éditions EDK, Groupe EDP Sciences, 2014)
The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern ...
Chroniques génomiques - Slide-seq : L'analyse d'expression à haute résolution spatiale
(EDP Sciences, 2019)
A newly developed technique allows the analysis of gene expression within tissues at near-cellular resolution. This opens a whole range of applications and will be a major ingredient of future studies.
Chroniques génomiques - Encore le « gène du crime » ?
(Éditions EDK, Groupe EDP Sciences, 2015)
A new genetic study focussing on the degree of violence in criminals and using both candidate gene and GWAS approaches finds statistically significant associations of extreme violent behaviour with low activity alleles of ...
Chroniques génomiques - Les pièges de l’amélioration
(EDP Sciences, 2019)
Inactivation of the CCR5 gene by CRISPR editing in human
embryos, as recently attempted in China, was touted as a positive change for the
babies involved since it was expected to ...
Chroniques génomiques - Espérance de vie et traces des cataclysmes
(Éditions EDK, Groupe EDP Sciences, 2017)
Life expectancy curves for several nations provide an astonishingly precise image of the major events that occurred during the last century, highlight similarities between France and Great Britain, and reflect the tremendous ...
Chroniques génomiques - Immunothérapie « CAR-T » : une autorisation qui fait date
(Éditions EDK, Groupe EDP Sciences, 2017)
The first therapy based on chimeric antigen receptors has been approved by the FDA. It gives excellent results in recurrent paediatric ALL; its cost is very high but fairly consistent with the clinical benefit (long term ...
Chroniques génomiques - Les « gènes » de la schizophrénie
(Éditions EDK, Groupe EDP Sciences, 2014)
Very large-scale GWAS analyses confirm the genetic complexity of schizophrenia and provide some new leads to understand the etiology of the condition.