The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out ...

Many developments in biology and biotechnology have relied on the HeLa cell line, originally derived in 1951 from a Black cancer patient without her knowledge. This origin became generally known at the turn of the century, ...

Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually ...

The existence of a number of highly similar rockfish species with very different life spans has motivated extensive DNA sequencing studies that have uncovered strong selection for genes involved in DNA maintenance and in ...

Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient ...