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dc.contributor.authorJordan, Bertrand-
dc.date.accessioned2018-09-27T09:49:41Z
dc.date.available2018-09-27T09:49:41Z
dc.date.issued2017
dc.identifier.citationJordan, Bertrand ; Chroniques génomiques - Les Argonautes ont-ils perdu le Nord ?, Med Sci (Paris), , Vol. 33, N° 2 ; p. 193-196 ; DOI : 10.1051/medsci/20173302016
dc.identifier.issn1958-5381
dc.identifier.urihttp://hdl.handle.net/10608/9124
dc.description.abstractA novel gene editing procedure based on a nuclease from the Argonaute protein family was described in mid-2016 and appeared to provide significant advantages over the now widely used CRISPR-Cas9 system. Attempts by numerous groups to use this technique have however been unsuccessful; several negative reports have been published in addition to many accounts of failure found in the “grey literature”. It is unclear at this point whether this reflects an (unknown) critical experimental factor or hints at data misinterpretation, possibly even at outright fabrication of results.en
dc.language.isofr
dc.publisherÉditions EDK, Groupe EDP Sciences
dc.relation.ispartofForum
dc.rightsArticle en libre accèsfr
dc.rightsMédecine/Sciences - Inserm - SRMSfr
dc.sourceM/S. Médecine sciences [ISSN papier : 0767-0974 ; ISSN numérique : 1958-5381], , Vol. 33, N° 2; p. 193-196
dc.subject.meshAnimauxfr
dc.subject.meshProtéines Argonautefr
dc.subject.meshSystèmes CRISPR-Casfr
dc.subject.meshÉdition de gènefr
dc.subject.meshHumainsfr
dc.subject.meshSourisfr
dc.subject.meshNatronobacteriumfr
dc.subject.meshBrevets comme sujetfr
dc.subject.meshAcides nucléiques peptidiquesfr
dc.subject.meshgénétiquefr
dc.subject.meshisolation et purificationfr
dc.subject.meshphysiologiefr
dc.subject.meshéthiquefr
dc.subject.meshlégislation et jurisprudencefr
dc.subject.meshméthodesfr
dc.subject.meshadministration et posologiefr
dc.titleChroniques génomiques - Les Argonautes ont-ils perdu le Nord ?fr
dc.title.alternativeAre the Argonauts lost at sea?en
dc.typeArticle
dc.contributor.affiliationUMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d’adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France
dc.contributor.affiliationCoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France
dc.identifier.doi10.1051/medsci/20173302016
dc.identifier.pmid28240212


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