Parcourir médecine/sciences 2016 - Volume 32 par auteur "Jordan, Bertrand"
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Chroniques génomiques - 23andMe et le mal des transports
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)A Genome Wide Association Study on propensity to motion sickness published by 23andMe gives interesting results, shows validity for self-reported phenotypic information and underlines the value of the model developed by ... -
Chroniques génomiques - Cancer :faut-il viser la lune ?
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)The recently announced “Cancer moonshot” may be greeted with scepticism: the previous “War on cancer” (1971) was not very successful. However the current plan seems well targeted, with emphasis not only on research investment ... -
Chroniques génomiques - Le Graal de Grail est-il un mirage ?
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)A newly established company called Grail and spun out from Illumina promises to develop a “liquid biopsy” test suitable for asymptomatic cancer detection and general screening. While the necessary sensitivity may be ... -
Chroniques génomiques - Les débuts de CRISPR en thérapie génique
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)Two clinical trials using CRISPR technology to engineer the T cells of cancer patients by inactivating the gene for immune checkpoint molecule PD-1 are (almost) underway, one in the USA and the other in China. The less ... -
Chroniques génomiques - Les spermatozoïdes de l’obésité
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)A demonstration of (somewhat) specific differential RNA content and DNA methylation in sperm from obese individuals opens the possibility of epigenetic transmission to offspring. -
Chroniques génomiques - Sommet de Washington : feu orange pour la thérapie germinale ?
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)The summit organised in early December 2015 considered in depth the various issues (technical, scientific, societal and ethical) raised by the prospect of genome editing using the extremely effective CRISPR system. Germline ... -
Chroniques génomiques - Synthétique, vous avez dit « Synthétique » ?
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)The synthesis of a minimal bacterial genome comprising only 473 genes is an impressive achievement, yet it is only a step towards a really synthetic genome based on first principles: this set of genes was derived from a ... -
Chroniques génomiques - « Explosion des cancers » : retour aux chiffres
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)The SEER site set up by the NCI provides an opportunity to generate ad hoc graphs of cancer statistics over the last forty years, makes it possible to examine commonly held assumptions such as a “cancer epidemic” and allows ... -
Chroniques génomiques- HGP-write : après la lecture, l’écriture ?
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)The recently proposed « HGP-write » project aims to synthetize a full human genome and to introduce it into cells. This ambitious endeavour is fraught with financial and technical uncertainties and, if successful, would ... -
Un Nobel pour la réparation de l’ADN : Prix Nobel de Chimie 2015 : Thomas Lindahl, Paul Modrich et Aziz Sankar :
Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)Le Prix Nobel de Chimie récompense cette année trois chercheurs qui ont découvert des mécanismes majeurs par lesquels les cellules réparent en permanence les altérations apparues dans leur ADN. Ces travaux remontent aux ...