• Chroniques génomiques - Cancer :faut-il viser la lune ? 

      Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)
      The recently announced “Cancer moonshot” may be greeted with scepticism: the previous “War on cancer” (1971) was not very successful. However the current plan seems well targeted, with emphasis not only on research investment ...
    • Chroniques génomiques - Le Graal de Grail est-il un mirage ? 

      Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)
      A newly established company called Grail and spun out from Illumina promises to develop a “liquid biopsy” test suitable for asymptomatic cancer detection and general screening. While the necessary sensitivity may be ...
    • Chroniques génomiques - Les débuts de CRISPR en thérapie génique 

      Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)
      Two clinical trials using CRISPR technology to engineer the T cells of cancer patients by inactivating the gene for immune checkpoint molecule PD-1 are (almost) underway, one in the USA and the other in China. The less ...
    • Chroniques génomiques - Les spermatozoïdes de l’obésité 

      Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)
      A demonstration of (somewhat) specific differential RNA content and DNA methylation in sperm from obese individuals opens the possibility of epigenetic transmission to offspring.
    • Chroniques génomiques - « Explosion des cancers » : retour aux chiffres 

      Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)
      The SEER site set up by the NCI provides an opportunity to generate ad hoc graphs of cancer statistics over the last forty years, makes it possible to examine commonly held assumptions such as a “cancer epidemic” and allows ...
    • Chroniques génomiques- HGP-write : après la lecture, l’écriture ? 

      Jordan, Bertrand (Éditions EDK, Groupe EDP Sciences, 2016)
      The recently proposed « HGP-write » project aims to synthetize a full human genome and to introduce it into cells. This ambitious endeavour is fraught with financial and technical uncertainties and, if successful, would ...