Recherche
Voici les éléments 11-18 de 18
Chroniques génomiques - Réparation de l’ADN et longévité : les rongeurs et nous
(EDP Sciences, 2022)
Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient ...
Vers une thérapie génique pour la progéria ?
(EDP Sciences, 2021)
Hutchinson-Gilford Progeria (acute premature aging) is caused by a de novo point mutation in the lamin A gene. Recently, this mutation has been accurately corrected by base editing in patient cell lines and in a mouse ...
Chroniques génomiques - La « dé-extinction » du mammouth laineux, un « Colossal » canular ?
(EDP Sciences, 2022)
Reports of a mammoth cloning project on-going under George Church’s supervision appear periodically in the press. Close examination of the available evidence indicates that there is indeed such a project (carried out in a ...
Chroniques génomiques - Chiens, loups et gènes
(EDP Sciences, 2022)
The most significant polymorphism associated with dog size occurs in the region of the
IGF1
gene and concerns a single base change in a neighbouring lncRNA. The “small” (C) ...
Chroniques génomiques - Un cadeau empoisonné
(EDP Sciences, 2020)
GWAS analysis of severe Covid patients implicates a major locus on chromosome 3. The corresponding 50 kb segment appears to originate from Neanderthal/Sapiens crossings, raising interesting evolutionary questions.
Chroniques génomiques - Néandertal et Afrique, le retour
(Éditions EDK, Groupe EDP Sciences, 2020)
Sophisticated analyses of current human populations compared to a high-coverage Neandertal genome sequence indicate that, contrary to the previous consensus, African genomes carry a small but significant amount of ...
Chroniques génomiques - Tout savoir sur les mutations germinales chez les vertébrés
(EDP Sciences, 2023)
Mutations in the germline are an essential component of evolution. Current DNA sequencing systems allow quantification of these mutations through full genome sequencing of father/mother/child trios. A recent paper reports ...
Chroniques génomiques - Naissance d’un gène
(EDP Sciences, 2023)
The availability of an extensive set of vertebrate genome sequences, together with large-scale transcriptome studies, has allowed the discovery of numerous non-canonical ORFs (usually quite short) with evidence of ...