Parcourir médecine/sciences 2019 - Volume 35 par auteur "Jordan, Bertrand"
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Bébés CRISPR : Anatomie d’une transgression
Jordan, Bertrand (EDP Sciences, 2019)Analysing the data recently presented by Jiankui He and assuming that it is authentic shows that the goal of abolishing the expression of CCR5 may have been reached for one of the resulting twins, although this remains to ... -
CCR5 et longévité : une rétraction
Jordan, Bertrand (EDP Sciences, 2019) -
Chroniques génomiques - Actualités du séquençage d’ADN
Jordan, Bertrand (EDP Sciences, 2019)The planned acquisition of Pacific Biosciences by Illumina could signal a big change in the DNA sequencing landscape, and provides the incentive for an update on a field that still has a number of players and could be ... -
Chroniques génomiques - Cent ans après, le retour de la phagothérapie ?
Jordan, Bertrand (EDP Sciences, 2019)Bacteriophages were advocated as therapeutic agents more than a century ago, but the advent of antibiotics relegated them to a very minor role. Today, multi-drug resistant bacteria are a serious health problem, and phage ... -
Chroniques génomiques - Couleur de la peau chez l’homme : de nouvelles surprises
Jordan, Bertrand (EDP Sciences, 2019)Careful GWAS analysis of a group of mixed-ancestry Latino-American individuals reveals the role of a new “light” variant of the MSFD12 gene which appears to originate in some of the ... -
Chroniques génomiques - Extension du domaine du codage : l’ADN hachimoji
Jordan, Bertrand (EDP Sciences, 2019)The synthesis of four new nucleotide analogues that can form hydrogen bonds within the DNA double helix and can be incorporated without distortion of the structure extends the possibilities of synthetic biology. Although ... -
Chroniques génomiques - Le monde caché des clones mutants dans les tissus normaux
Jordan, Bertrand (EDP Sciences, 2019)Careful sequencing studies on small samples of normal oesophageal epithelium reveal the presence of very abundant cellular clones harbouring mutations in known cancer genes (and elsewhere). The number and size of these ... -
Chroniques génomiques - Les limites de l’« oncologie de précision »
Jordan, Bertrand (EDP Sciences, 2019)The concept of precision oncology is straightforward, but the actual results of treating advanced cancer patients with the targeted drug suggested by genomic analysis have been generally disappointing, indicating that this ... -
Chroniques génomiques - Les pièges de l’amélioration
Jordan, Bertrand (EDP Sciences, 2019)Inactivation of the CCR5 gene by CRISPR editing in human embryos, as recently attempted in China, was touted as a positive change for the babies involved since it was expected to ... -
Chroniques génomiques - Slide-seq : L'analyse d'expression à haute résolution spatiale
Jordan, Bertrand (EDP Sciences, 2019)A newly developed technique allows the analysis of gene expression within tissues at near-cellular resolution. This opens a whole range of applications and will be a major ingredient of future studies.