Relationship between depression and blood cytokine levels in lung cancer patients
Date
2018Auteur
Liu, Wen-Juan
Wang, Xiao-Dan
Wu, Wei
Huang, Xiao
Metadata
Afficher la notice complèteRésumé
Objective: To study the correlation between depression and blood cytokine levels in lung cancer patients. Methods: 92 patients with advanced lung cancer were evaluated for depression using the scoring index of depression self-rating scale. Lack of depression (n=24), mild depression (n=45), and moderate depression (n=23) were found in the cohort. Meanwhile, 40 healthy subjects were selected as the control group. The levels of IL-10, IL-6, IL-8, and TNF-α in each group were detected by sandwich enzyme-linked immunosorbent assays, and their correlation with the degree of depression was analyzed. Results: The levels of IL-10, IL-6, IL-8, and TNF-α were all higher than those in the control group (P<0.05). Moreover, the depression statuses of patients with lung cancer were positively correlated with IL-10, IL-6, and TNF-α levels (r = 0.705, 0.301, and 0.446, P<0.01); however, the level of IL-8 was not relevant (r=0.136, p>0.05). Conclusion: Serum levels of IL-10, IL-6, and TNF-α are associated with depression scoring in patients with lung cancer.
Pour citer ce document
Liu, Wen-Juan ; Wang, Xiao-Dan ; Wu, Wei ; Huang, Xiao ; Relationship between depression and blood cytokine levels in lung cancer patients, Med Sci (Paris), , Vol. 34, N° HS ; p. 113-115 ; DOI : 10.1051/medsci/201834f119