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Chroniques génomiques - Sommet de Washington : feu orange pour la thérapie germinale ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The summit organised in early December 2015 considered in depth the various issues (technical, scientific, societal and ethical) raised by the prospect of genome editing using the extremely effective CRISPR system. Germline ...
Chroniques génomiques - CRISPR-Cas9, une nouvelle donne pour la thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2015)
Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; ...
Chroniques génomiques - Modification ciblée du génome : une nouvelle approche prometteuse
(Éditions EDK, Groupe EDP Sciences, 2017)
A new approach, based on the use of peptide nucleic acid molecules to form triple helices and promote locus-specific recombination, demonstrates potential for in vivo gene correction at clinically significant levels and ...
Chroniques génomiques - CRISPR sur embryons humains : une nouvelle étape
(Éditions EDK, Groupe EDP Sciences, 2017)
Viable human embryos carrying a disease mutation have now been corrected by CRISPR-Cas9 editing. Although the correction is not perfect, and the embryos have not been implanted, this brings us closer to human germline ...