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Chroniques génomiques - De l’exome à l’avatar : vers une « oncologie de précision » ?
(Éditions EDK, Groupe EDP Sciences, 2014)
According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ...
Chroniques génomiques - CRISPR-Cas9, une nouvelle donne pour la thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2015)
Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; ...
Chroniques génomiques : L’insoutenable complexité des cancers
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques : Remise en cause du « dogme central »
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques : La génétique du trou de souris
(Éditions EDK/Groupe EDP Sciences, 2013)
The Oldfield mouse and the Deer mouse build very different burrows in nature and also in the laboratory. This behaviour is innate and, in a series of beautiful experiments making use of new generation sequencing for genetic ...
Chroniques génomiques - Les Argonautes ont-ils perdu le Nord ?
(Éditions EDK, Groupe EDP Sciences, 2017)
A novel gene editing procedure based on a nuclease from the Argonaute protein family was described in mid-2016 and appeared to provide significant advantages over the now widely used CRISPR-Cas9 system. Attempts by numerous ...
Chroniques génomiques : Du bon usage des exomes
(EDK, 2010)
Hémophilie : la thérapie génique, enfin… : Chroniques Génomiques
(EDP Sciences, 2018)
Recent efforts at gene therapy for haemophilia A and B using AAV-derived vectors show durable expression of coagulation factors at significant levels, resulting in almost complete correction of the phenotype. This is the ...
Chroniques génomiques : Des signatures sans valeur ?
(Éditions EDK/Groupe EDP Sciences, 2012)
Chroniques génomiques : Néandertal et Homo sapiens : To meet, or not to meet?
(Éditions EDK/Groupe EDP Sciences, 2012)