Recherche
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Chroniques génomiques - De l’exome à l’avatar : vers une « oncologie de précision » ?
(Éditions EDK, Groupe EDP Sciences, 2014)
According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ...
Chroniques génomiques - Dépistage du cancer : les promesses illusoires de Pathway Genomics
(Éditions EDK, Groupe EDP Sciences, 2015)
The “liquid biopsy” approach shows promise for characterization and monitoring of cancer during treatment; however a blood-based detection test for “high-risk” but asymptomatic individuals, recently introduced by Pathway ...
Chroniques génomiques - Cancer :faut-il viser la lune ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The recently announced “Cancer moonshot” may be greeted with scepticism: the previous “War on cancer” (1971) was not very successful. However the current plan seems well targeted, with emphasis not only on research investment ...
Chroniques génomiques - Le Graal de Grail est-il un mirage ?
(Éditions EDK, Groupe EDP Sciences, 2016)
A newly established company called Grail and spun out from Illumina promises to develop a “liquid biopsy” test suitable for asymptomatic cancer detection and general screening. While the necessary sensitivity may be ...
Chroniques génomiques : L’insoutenable complexité des cancers
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques - L’invasion des tests non invasifs
(EDP Sciences, 2014)
Non-invasive prenatal testing is becoming commonplace, but, in addition, other tests using only a blood sample are being developed and will have a significant impact, notably in oncology.
Chroniques génomiques - « Explosion des cancers » : retour aux chiffres
(Éditions EDK, Groupe EDP Sciences, 2016)
The SEER site set up by the NCI provides an opportunity to generate ad hoc graphs of cancer statistics over the last forty years, makes it possible to examine commonly held assumptions such as a “cancer epidemic” and allows ...
Chroniques génomiques : Les points critiques du séquençage clinique
(Éditions EDK/Groupe EDP Sciences, 2012)
Chroniques génomiques - Hétérogénéité des tumeurs : l’apport du séquençage sur cellules individuelles
(Éditions EDK, Groupe EDP Sciences, 2014)
The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern ...
Chroniques génomiques - Cancer : les trois époques de la médecine personnalisée :
(Éditions EDK, Groupe EDP Sciences, 2017)
Since the completion of the first human DNA sequence, genomic approaches have penetrated into cancer research and therapy: first through expression profiling for diagnostic, prognostic and predictive purposes, then by ...