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Chroniques génomiques - Sommet de Washington : feu orange pour la thérapie germinale ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The summit organised in early December 2015 considered in depth the various issues (technical, scientific, societal and ethical) raised by the prospect of genome editing using the extremely effective CRISPR system. Germline ...
Chroniques génomiques - Modification ciblée du génome : une nouvelle approche prometteuse
(Éditions EDK, Groupe EDP Sciences, 2017)
A new approach, based on the use of peptide nucleic acid molecules to form triple helices and promote locus-specific recombination, demonstrates potential for in vivo gene correction at clinically significant levels and ...
Chroniques génomiques - Les pièges de l’amélioration
(EDP Sciences, 2019)
Inactivation of the CCR5 gene by CRISPR editing in human
embryos, as recently attempted in China, was touted as a positive change for the
babies involved since it was expected to ...
Chroniques génomiques - Les Argonautes ont-ils perdu le Nord ?
(Éditions EDK, Groupe EDP Sciences, 2017)
A novel gene editing procedure based on a nuclease from the Argonaute protein family was described in mid-2016 and appeared to provide significant advantages over the now widely used CRISPR-Cas9 system. Attempts by numerous ...
Chroniques génomiques - CRISPR sur embryons humains : une nouvelle étape
(Éditions EDK, Groupe EDP Sciences, 2017)
Viable human embryos carrying a disease mutation have now been corrected by CRISPR-Cas9 editing. Although the correction is not perfect, and the embryos have not been implanted, this brings us closer to human germline ...