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Chroniques génomiques : Une publication impulsive…
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques - Thérapie génique germinale, le retour ?
(Éditions EDK, Groupe EDP Sciences, 2015)
The recent development of a powerful and flexible genome editing technique (the CRISP-cas9 method) accelerates tremendously the production of animal models and will significantly enhance the perspectives of (somatic) gene ...
Chroniques génomiques - De l’exome à l’avatar : vers une « oncologie de précision » ?
(Éditions EDK, Groupe EDP Sciences, 2014)
According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ...
Chroniques génomiques - Dépistage du cancer : les promesses illusoires de Pathway Genomics
(Éditions EDK, Groupe EDP Sciences, 2015)
The “liquid biopsy” approach shows promise for characterization and monitoring of cancer during treatment; however a blood-based detection test for “high-risk” but asymptomatic individuals, recently introduced by Pathway ...
Chroniques génomiques - Les débuts de CRISPR en thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2016)
Two clinical trials using CRISPR technology to engineer the T cells of cancer patients by inactivating the gene for immune checkpoint molecule PD-1 are (almost) underway, one in the USA and the other in China. The less ...
Chroniques génomiques - Les leçons inattendues d’Hiroshima
(Éditions EDK, Groupe EDP Sciences, 2014)
One of the initial motivations for the Genome project was to improve the detection of possible mutations in children of atomic bomb survivors. In fact it has proved very difficult to find any genetic effect in these ...
Chroniques génomiques : Un chapeau pour mon repas ?
(Éditions EDK/Groupe EDP Sciences, 2013)
After clearing many hurdles, gene therapy is now reaching the commercialization stage and can be expected to make a modest but real contribution to treatment in the near future.
Chroniques génomiques - Le Graal de Grail est-il un mirage ?
(Éditions EDK, Groupe EDP Sciences, 2016)
A newly established company called Grail and spun out from Illumina promises to develop a “liquid biopsy” test suitable for asymptomatic cancer detection and general screening. While the necessary sensitivity may be ...
Chroniques génomiques - CRISPR-Cas9, une nouvelle donne pour la thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2015)
Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; ...
Chroniques génomiques : L’insoutenable complexité des cancers
(Éditions EDK/Groupe EDP Sciences, 2011)