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Chroniques génomiques - Thérapie génique germinale, le retour ?
(Éditions EDK, Groupe EDP Sciences, 2015)
The recent development of a powerful and flexible genome editing technique (the CRISP-cas9 method) accelerates tremendously the production of animal models and will significantly enhance the perspectives of (somatic) gene ...
Chroniques génomiques - Séquençage d’ADN: l’offensive des nanopores
(Éditions EDK, Groupe EDP Sciences, 2017)
A practical DNA sequencer based on nanopores has now demonstrated interesting performance and may be on the way to capturing a significant slice of the sequencing market while opening up new application fields thanks to ...
Chroniques génomiques - Les débuts de CRISPR en thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2016)
Two clinical trials using CRISPR technology to engineer the T cells of cancer patients by inactivating the gene for immune checkpoint molecule PD-1 are (almost) underway, one in the USA and the other in China. The less ...
Chroniques génomiques - CRISPR-Cas9, une nouvelle donne pour la thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2015)
Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; ...
Chroniques génomiques - 23andMe et le mal des transports
(Éditions EDK, Groupe EDP Sciences, 2016)
A Genome Wide Association Study on propensity to motion sickness published by 23andMe gives interesting results, shows validity for self-reported phenotypic information and underlines the value of the model developed by ...
Chroniques génomiques : L’intimité génétique existe-t-elle encore ?
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques - Séquencer les bébés ?
(Éditions EDK, Groupe EDP Sciences, 2015)
An extension of newborn screening to genome sequencing is now feasible but raises a number of scientific, organisational and ethical issues. This is being explored in discussions and in several funded trials, in order to ...
Chroniques génomiques - Biopsies liquides, une révolution en cancérologie ?
(Éditions EDK, Groupe EDP Sciences, 2015)
The detection and analysis of circulating tumour DNA and/or circulating tumour cells in the blood of cancer patients open new possibilities for cancer characterisation and management. The approach has generated much ...
Chroniques génomiques - L’invasion des tests non invasifs
(EDP Sciences, 2014)
Non-invasive prenatal testing is becoming commonplace, but, in addition, other tests using only a blood sample are being developed and will have a significant impact, notably in oncology.
Chroniques génomiques : Les points critiques du séquençage clinique
(Éditions EDK/Groupe EDP Sciences, 2012)