Recherche
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Chroniques génomiques - Le monde caché des clones mutants dans les tissus normaux
(EDP Sciences, 2019)
Careful sequencing studies on small samples of normal oesophageal epithelium reveal the presence of very abundant cellular clones harbouring mutations in known cancer genes (and elsewhere). The number and size of these ...
Chroniques génomiques - La sénescence en passe d’être vaincue ?
(EDP Sciences, 2018)
Senescent cells are involved in many age-related diseases, and the effects of their elimination by “senolytic” drugs is an active research field. A recent paper describes a convenient murine model of induced senescence and ...
Chroniques génomiques : Nous avons les moyens de faire parler votre ADN…
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques - La longévité des sébastes
(EDP Sciences, 2022)
The existence of a number of highly similar rockfish species with very different life spans has motivated extensive DNA sequencing studies that have uncovered strong selection for genes involved in DNA maintenance and in ...
Chroniques génomiques - Les sénolytiques contre la Covid-19 ?
(EDP Sciences, 2021)
The elimination of some senescent cells by « senolytic » compounds can greatly improve the health of aged mice and in some cases reverse the effects of aging. Using a microbial exposure system that closely models coronavirus ...
Chroniques génomiques - Mutations somatiques et longévité
(EDP Sciences, 2022)
New approaches allow precise measurement of somatic mutations in tissues. Applied to a diverse set of mammals, these methods show that somatic mutation load increases with age (as expected) but reaches similar levels near ...