Viable human embryos carrying a disease mutation have now been corrected by CRISPR-Cas9 editing. Although the correction is not perfect, and the embryos have not been implanted, this brings us closer to human germline ...

Since the completion of the first human DNA sequence, genomic approaches have penetrated into cancer research and therapy: first through expression profiling for diagnostic, prognostic and predictive purposes, then by ...

Parasites intracellulaires obligatoires, les virus dépendent d’un grand nombre de facteurs cellulaires pour accomplir leur cycle de multiplication. Parmi ceux-ci, les microARN (miARN) ont récemment émergé comme d’importants ...

In clinical oncology, obtaining sequence data from tumour samples has become practical in terms of logistics, turnover time and costs. The major issue now is the interpretation of this sequence to define actionable targets, ...

Alternative bases that can fit into the DNA double helix have now been used in vivo to direct the synthesis of proteins incorporating unnatural amino acids. This bioengineering feat is significant at both the conceptual ...

Dans le cadre pénal, l’analyse d’une vingtaine de marqueurs génétiques résulte en un profil génétique discriminant permettant d’établir ou d’exclure un rapprochement entre une trace biologique relevée sur une scène ...

Recent efforts at gene therapy for haemophilia A and B using AAV-derived vectors show durable expression of coagulation factors at significant levels, resulting in almost complete correction of the phenotype. This is the ...