GWAS analysis of severe Covid patients implicates a major locus on chromosome 3. The corresponding 50 kb segment appears to originate from Neanderthal/Sapiens crossings, raising interesting evolutionary questions.

The prediction of a person’s aspect from analysis of an anonymous DNA sample has made significant progress in the last decade. Pigmentation (eyes, hair and, more recently, skin colour) can now be determined with good ...

Risk assessment for a cancer type with moderate heritability can be accurately performed using a relatively small number of SNPs detected by GWAS analyses to calculate a polygenic risk score (PRS) that has definite clinical ...

Evidence for a “homosexuality gene” was claimed in the early 1990’s on the basis of linkage studies that, by current criteria, were woefully underpowered. Indeed, follow up studies gave contradictory results. Genome-wide ...

The combination of 281 GWAS studies for adult height leads to the identification of 12,111 SNP in 7,209 loci that together account for essentially all SNP heritability for this trait: there is no longer any significant ...