Mémoire olfactive et migration neuronale chez l'adulte.

Abstract

Neuroblasts in the subventricular zone of the walls of the lateral ventricle in the brain of young and adult rodents migrate into the olfactory bulb where they differentiate into local inter-neurons. These cells move closely associated with each other, forming chains without radial glial or axonal guidance. The migrating neuroblasts express PSA-NCAM on their surface and PSA residues are crucial for cell-cell interaction during chain migration. Cells remain organized as a chain formed by homotypic interactions between cells until they reach the olfactory bulb, where they disperse radially as individual neurons, we propose that a combination of neurogenesis and neuronal replacement in the olfactory system provides unique advantages for olfactory learning. [References: 41]