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Voici les éléments 2394-2413 de 13215
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Chroniques génomiques - De HGP-write aux « super-cellules »
(EDP Sciences, 2018)The HGP-write project, announced in 2016 but not really implemented yet, comes back as a project aimed at constructing an “ultra-safe” human cell line fully resistant to virus infection and with other desirable characteristics. ... -
Chroniques génomiques - De l’exome à l’avatar : vers une « oncologie de précision » ?
(Éditions EDK, Groupe EDP Sciences, 2014)According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ... -
Chroniques génomiques - Des résultats tout à fait inattendus
(Éditions EDK, Groupe EDP Sciences, 2015)There are now a number of cases in which non-invasive prenatal testing (NIPT) has detected signs of cancer in pregnant women. These unexpected findings raise a number of difficult questions regarding their communication ... -
Chroniques génomiques - Dépistage du cancer : les promesses illusoires de Pathway Genomics
(Éditions EDK, Groupe EDP Sciences, 2015)The “liquid biopsy” approach shows promise for characterization and monitoring of cancer during treatment; however a blood-based detection test for “high-risk” but asymptomatic individuals, recently introduced by Pathway ... -
Chroniques génomiques - Dépister les cancers asymptomatiques ?
(EDP Sciences, 2018)A recent publication describes a sophisticated “liquid biopsy” procedure that analyses both tumoral DNA and proteins present in peripheral blood to provide sensitive detection of different types of cancer. These results ... -
Chroniques génomiques - Du bon usage d’un test non invasif
(Éditions EDK, Groupe EDP Sciences, 2015) -
Chroniques génomiques - Encore le « gène du crime » ?
(Éditions EDK, Groupe EDP Sciences, 2015)A new genetic study focussing on the degree of violence in criminals and using both candidate gene and GWAS approaches finds statistically significant associations of extreme violent behaviour with low activity alleles of ... -
Chroniques génomiques - Espérance de vie et traces des cataclysmes
(Éditions EDK, Groupe EDP Sciences, 2017)Life expectancy curves for several nations provide an astonishingly precise image of the major events that occurred during the last century, highlight similarities between France and Great Britain, and reflect the tremendous ... -
Chroniques génomiques - Espérance de vie et Covid : remettre les pendules à l’heure
(EDP Sciences, 2022)Life expectancy (LE) is an objective and highly reliable marker for events affecting demography. Analysing LE changes during the Covid pandemic shows widely different situations in a sample of 29 countries, highlighting ... -
Chroniques génomiques - Extension du domaine du codage : l’ADN hachimoji
(EDP Sciences, 2019)The synthesis of four new nucleotide analogues that can form hydrogen bonds within the DNA double helix and can be incorporated without distortion of the structure extends the possibilities of synthetic biology. Although ... -
Chroniques génomiques - Édition de gènes in vivo et thérapie génique
(EDP Sciences, 2021)In vivo gene editing has been achieved in a phase I clinical trial and results in a strong reduction of the level of a pathogenic protein. While preliminary, these results open the way for many ... -
Chroniques génomiques - Gènes et longévité : nouvelles données, nouvelles controverses
(EDP Sciences, 2018)Analysis of a huge human pedigree constructed using public genealogy databases indicates that the heritability of longevity is probably lower than previously accepted (0.10 to 0.15 instead of 0.25 to 0.30). This makes the ... -
Chroniques génomiques - Henrietta Lacks et les cellules HeLa : Les leçons d’une histoire
(Éditions EDK/Groupe EDP Sciences, 2013)An exceptional arrangement concluded for access to the HeLa cell line sequence highlights the problems involved in studies on « old » samples obtained before ethical and privacy safeguards were in place. -
Chroniques génomiques - Hétérogénéité des tumeurs : l’apport du séquençage sur cellules individuelles
(Éditions EDK, Groupe EDP Sciences, 2014)The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern ... -
Chroniques génomiques - Immunothérapie « CAR-T » : une autorisation qui fait date
(Éditions EDK, Groupe EDP Sciences, 2017)The first therapy based on chimeric antigen receptors has been approved by the FDA. It gives excellent results in recurrent paediatric ALL; its cost is very high but fairly consistent with the clinical benefit (long term ... -
Chroniques génomiques - La longévité des sébastes
(EDP Sciences, 2022)The existence of a number of highly similar rockfish species with very different life spans has motivated extensive DNA sequencing studies that have uncovered strong selection for genes involved in DNA maintenance and in ... -
Chroniques génomiques - La sénescence en passe d’être vaincue ?
(EDP Sciences, 2018)Senescent cells are involved in many age-related diseases, and the effects of their elimination by “senolytic” drugs is an active research field. A recent paper describes a convenient murine model of induced senescence and ... -
Chroniques génomiques - La « dé-extinction » du mammouth laineux, un « Colossal » canular ?
(EDP Sciences, 2022)Reports of a mammoth cloning project on-going under George Church’s supervision appear periodically in the press. Close examination of the available evidence indicates that there is indeed such a project (carried out in a ... -
Chroniques génomiques - Le dépistage du cancer sauve-t-il vraiment des vies ?
(EDP Sciences, 2023)Systematic screening for specific cancers has been shown to reduce cancer-specific mortality, but has not demonstrated an effect on all-cause mortality. This paradox is due to minor but frequent risks of screening bearing ... -
Chroniques génomiques - Le Graal de Grail est-il un mirage ?
(Éditions EDK, Groupe EDP Sciences, 2016)A newly established company called Grail and spun out from Illumina promises to develop a “liquid biopsy” test suitable for asymptomatic cancer detection and general screening. While the necessary sensitivity may be ...