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Chroniques génomique : Programmes génome : une overdose de commentaires ?
(John Libbey Eurotext, Montrouge, 1991) -
Chroniques génomiques
(John Libbey Eurotext, Montrouge, 1990) -
Chroniques génomiques - 23andMe et le mal des transports
(Éditions EDK, Groupe EDP Sciences, 2016)A Genome Wide Association Study on propensity to motion sickness published by 23andMe gives interesting results, shows validity for self-reported phenotypic information and underlines the value of the model developed by ... -
Chroniques génomiques - 23andMe ou comment (très bien) valoriser ses clients
(Éditions EDK, Groupe EDP Sciences, 2015)The announcement of several deals between the DTC genetics firm 23andMe and Genentech, Pfizer and other corporations reveals the real business model of the company: selling access to sets of characterized patients for ... -
Chroniques génomiques - Actualités du séquençage d’ADN
(EDP Sciences, 2019)The planned acquisition of Pacific Biosciences by Illumina could signal a big change in the DNA sequencing landscape, and provides the incentive for an update on a field that still has a number of players and could be ... -
Chroniques génomiques - AlphaFold : un pas essentiel vers la fonction des protéines
(EDP Sciences, 2021) -
Chroniques génomiques - Balayage du génome et repérage des personnes à risque : Des GWAS aux GPS
(EDP Sciences, 2018)The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out ... -
Chroniques génomiques - Biopsies liquides, une révolution en cancérologie ?
(Éditions EDK, Groupe EDP Sciences, 2015)The detection and analysis of circulating tumour DNA and/or circulating tumour cells in the blood of cancer patients open new possibilities for cancer characterisation and management. The approach has generated much ... -
Chroniques génomiques - Cancer : les trois époques de la médecine personnalisée :
(Éditions EDK, Groupe EDP Sciences, 2017)Since the completion of the first human DNA sequence, genomic approaches have penetrated into cancer research and therapy: first through expression profiling for diagnostic, prognostic and predictive purposes, then by ... -
Chroniques génomiques - Cancer :faut-il viser la lune ?
(Éditions EDK, Groupe EDP Sciences, 2016)The recently announced “Cancer moonshot” may be greeted with scepticism: the previous “War on cancer” (1971) was not very successful. However the current plan seems well targeted, with emphasis not only on research investment ... -
Chroniques génomiques - Cent ans après, le retour de la phagothérapie ?
(EDP Sciences, 2019)Bacteriophages were advocated as therapeutic agents more than a century ago, but the advent of antibiotics relegated them to a very minor role. Today, multi-drug resistant bacteria are a serious health problem, and phage ... -
Chroniques génomiques - Ces bons mutants qui éliminent les tumeurs
(EDP Sciences, 2022)Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually ... -
Chroniques génomiques - Chiens, loups et gènes
(EDP Sciences, 2022)The most significant polymorphism associated with dog size occurs in the region of the IGF1 gene and concerns a single base change in a neighbouring lncRNA. The “small” (C) ... -
Chroniques génomiques - Clap de fin pour le « gène de l’homosexualité »
(EDP Sciences, 2020)Evidence for a “homosexuality gene” was claimed in the early 1990’s on the basis of linkage studies that, by current criteria, were woefully underpowered. Indeed, follow up studies gave contradictory results. Genome-wide ... -
Chroniques génomiques - Couleur de la peau chez l’homme : de nouvelles surprises
(EDP Sciences, 2019)Careful GWAS analysis of a group of mixed-ancestry Latino-American individuals reveals the role of a new “light” variant of the MSFD12 gene which appears to originate in some of the ... -
Chroniques génomiques - CRISPR sur embryons humains : une nouvelle étape
(Éditions EDK, Groupe EDP Sciences, 2017)Viable human embryos carrying a disease mutation have now been corrected by CRISPR-Cas9 editing. Although the correction is not perfect, and the embryos have not been implanted, this brings us closer to human germline ... -
Chroniques génomiques - CRISPR-Cas9, une nouvelle donne pour la thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2015)Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; ... -
Chroniques génomiques - De HGP-write aux « super-cellules »
(EDP Sciences, 2018)The HGP-write project, announced in 2016 but not really implemented yet, comes back as a project aimed at constructing an “ultra-safe” human cell line fully resistant to virus infection and with other desirable characteristics. ... -
Chroniques génomiques - De l’exome à l’avatar : vers une « oncologie de précision » ?
(Éditions EDK, Groupe EDP Sciences, 2014)According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ...