Recherche
Voici les éléments 41-50 de 79
Chroniques génomiques - CRISPR sur embryons humains : une nouvelle étape
(Éditions EDK, Groupe EDP Sciences, 2017)
Viable human embryos carrying a disease mutation have now been corrected by CRISPR-Cas9 editing. Although the correction is not perfect, and the embryos have not been implanted, this brings us closer to human germline ...
Chroniques génomiques - Cancer : les trois époques de la médecine personnalisée :
(Éditions EDK, Groupe EDP Sciences, 2017)
Since the completion of the first human DNA sequence, genomic approaches have penetrated into cancer research and therapy: first through expression profiling for diagnostic, prognostic and predictive purposes, then by ...
Recherche cibles, désespérément : Chroniques génomiques
(Éditions EDK, Groupe EDP Sciences, 2015)
In clinical oncology, obtaining sequence data from tumour samples has become practical in terms of logistics, turnover time and costs. The major issue now is the interpretation of this sequence to define actionable targets, ...
Chroniques génomiques - Variants fréquents et rares, caractères multigéniques et héritabilité perdue
(Éditions EDK, Groupe EDP Sciences, 2017)
Recently, a systematic (but limited) search for rare variants implicated in adult height, a highly polygenic trait, has uncovered a number of new variants for which the effect size is inversely correlated with the minor ...
Bases alternatives et organismes synthétiques : Chroniques Génomiques
(EDP Sciences, 2018)
Alternative bases that can fit into the DNA double helix have now been used in vivo to direct the synthesis of proteins incorporating unnatural amino acids. This bioengineering feat is significant at both the conceptual ...
Hémophilie : la thérapie génique, enfin… : Chroniques Génomiques
(EDP Sciences, 2018)
Recent efforts at gene therapy for haemophilia A and B using AAV-derived vectors show durable expression of coagulation factors at significant levels, resulting in almost complete correction of the phenotype. This is the ...
Chroniques génomiques - Le monde caché des clones mutants dans les tissus normaux
(EDP Sciences, 2019)
Careful sequencing studies on small samples of normal oesophageal epithelium reveal the presence of very abundant cellular clones harbouring mutations in known cancer genes (and elsewhere). The number and size of these ...
Chroniques génomiques : The sound of silence
(Éditions EDK/Groupe EDP Sciences, 2012)
Chroniques génomiques : Rare is frequent
(Éditions EDK/Groupe EDP Sciences, 2012)
Chroniques génomiques - Gènes et longévité : nouvelles données, nouvelles controverses
(EDP Sciences, 2018)
Analysis of a huge human pedigree constructed using public genealogy databases indicates that the heritability of longevity is probably lower than previously accepted (0.10 to 0.15 instead of 0.25 to 0.30). This makes the ...