MS 1996 num. 11 http://hdl.handle.net/10608/234 2026-04-22T18:14:12Z 2026-04-22T18:14:12Z La génétique de la stérilité masculine Bourgeron, T Barbaux, S McElreavey, K Fellous, M http://hdl.handle.net/10608/672 2019-03-20T10:36:21Z 1996-01-01T00:00:00Z La génétique de la stérilité masculine Bourgeron, T; Barbaux, S; McElreavey, K; Fellous, M About 15 % of couples world wide are affected by sterility problems. A substantial genetic component in male infertility is indicated by familial cases and de novo chromosomal rearrangements associated with the phenotype. Relatively little research has focused on the genetic aetiology of this frequent problem, whose the genetic causes are thus still unknown. Recent progress in understanding the genetics of meiosis in other organisms such as yeast and mice may permit the isolation of human homologous genes involved in this process. In this respect a number of homozygous null mutant mice (" knockout " mice) have been described where the only phenotypic abnormality is an absence of spermatogenesis. These genes represent excellent candidates for human male idiopathic infertility. Surprisingly, no gene mutations have been described in man that cause only a defect in spermatogenesis. A better understanding of the genetics of spermatogenesis should provide simple procedures to evaluate potential male carriers prior to expensive assisted reproductive techniques. It should also provide a knowledge-based approach to the management and treatment of male infertility. Such information should allow the development of effective fertility treatments, possibly through gene therapy, and of novel, reversible, male contraceptives. 1996-01-01T00:00:00Z Brèves http://hdl.handle.net/10608/673 2019-03-20T10:43:08Z 1996-01-01T00:00:00Z Brèves 1996-01-01T00:00:00Z Le déclin du français médical en Europe et aux Etats-Unis Navarro, F http://hdl.handle.net/10608/670 2019-03-20T10:36:35Z 1996-01-01T00:00:00Z Le déclin du français médical en Europe et aux Etats-Unis Navarro, F 1996-01-01T00:00:00Z Médecine à Peter C. Doherty et Rolf M Zinkernagel. La restriction de la réponse immunitaire par le complexe majeur d'histocompatibilité Lotteau, V http://hdl.handle.net/10608/671 2019-03-20T10:36:40Z 1996-01-01T00:00:00Z Médecine à Peter C. Doherty et Rolf M Zinkernagel. La restriction de la réponse immunitaire par le complexe majeur d'histocompatibilité Lotteau, V 1996-01-01T00:00:00Z