1.
Bonay
M
,
Aubier
M
. Pollution atmosphérique et maladies respiratoires allergiques . Med Sci (Paris).
2007; ; 23 : :187.–192.
2.
Yamamoto
T
,
Sakaguchi
N
,
Hachiya
M
, et al.
Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger . Leukemia.
2009; ; 23 : :761.–769.
3.
Rangasamy
T
,
Williams
MA
,
Bauer
S
, et al.
Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract . Am J Respir Cell Mol Biol.
2010; ; 43 : :276.–285.
4.
Walters
DM
,
Cho
HY
,
Kleeberger
SR
. Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2 . Antioxid Redox Signal.
2008; ; 10 : :321.–332.
5.
Boutten
A
,
Goven
D
,
Boczkowski
J
,
Bonay
M
. Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway . Expert Opin Ther Targets.
2010; ; 14 : :329.–346.
6.
Valko
M
,
Leibfritz
D
,
Moncol
J
, et al.
Free radicals and antioxidants in normal physiological functions and human disease . Int J Biochem Cell Biol.
2007; ; 39 : :44.–84.
Valko
M
,
Leibfritz
D
,
Moncol
J
, et al.
Free radicals and antioxidants in normal physiological functions and human disease . Int J Biochem Cell Biol.
2007; ; 39 : :44.–84.
7.
Leonarduzzi
G
,
Sottero
B
,
Poli
G
. Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited . Pharmacol Ther.
2010; ; 128 : :336.–374.
8.
Sykiotis
GP
,
Bohmann
D
. Stress-activated cap’n’collar transcription factors in aging and human disease . Sci Signal.
2010; ; 3 : :re3..
9.
Kensler
TW
,
Wakabayashi
N
,
Biswal
S
. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway . Annu Rev Pharmacol Toxicol.
2007; ; 47 : :89.–116.
10.
Gong
X
,
Kole
L
,
Iskander
K
,
Jaiswal
AK
. NRH: quinone oxidoreductase 2 and NAD(P)H: quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53 . Cancer Res.
2007; ; 67 : :5380.–5388.
11.
Morse
D
,
Choi
AM
. Heme oxygenase-1: from bench to bedside . Am J Respir Crit Care Med.
2005; ; 172 : :660.–670.
12.
Malhotra
D
,
Portales-Casamar
E
,
Singh
A
, et al.
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis . Nucleic Acids Res.
2010; ; 38 : :5718.–5734.
13.
Yoshida
T
,
Tuder
RM
. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease . Physiol Rev.
2007; ; 87 : :1047.–1082.
14.
Shaykhiev
R
,
Krause
A
,
Salit
J
, et al.
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease . J Immunol.
2009; ; 183 : :2867.–2883.
15.
Hogg
JC
,
Timens
W
. The pathology of chronic obstructive pulmonary disease . Annu Rev Pathol.
2009; ; 4 : :435.–459.
16.
Goven
D
,
Boutten
A
,
Lecon-Malas
V
, et al.
Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema . Thorax.
2008; ; 63 : :916.–924.
17.
Goven
D
,
Boutten
A
,
Lecon-Malas
V
, et al.
Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK . FEBS Lett.
2009; ; 583 : :3508.–3518.
18.
Malhotra
D
,
Thimmulappa
R
,
Navas-Acien
A
, et al.
Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1 . Am J Respir Crit Care Med.
2008; ; 178 : :592.–604.
19.
Malhotra
D
,
Thimmulappa
R
,
Vij
N
, et al.
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity . Am J Respir Crit Care Med.
2009; ; 180 : :1196.–1207.
20.
Siedlinski
M
,
Postma
DS
,
Boer
JM
, et al.
Level, course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population . Respir Res.
2009; ; 10 : :73..
21.
Strieter
RM
,
Mehrad
B
. New mechanisms of pulmonary fibrosis . Chest.
2009; ; 136 : :1364.–1370.
22.
Hecker
L
,
Vittal
R
,
Jones
T
, et al.
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury . Nat Med.
2009; ; 15 : :1077.–1081.
23.
Braun
S
,
Hanselmann
C
,
Gassmann
MG
, et al.
Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound . Mol Cell Biol.
2002; ; 22 : :5492.–5505.
24.
Bakin
AV
,
Stourman
NV
,
Sekhar
KR
, et al.
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins . Free Radic Biol Med.
2005; ; 38 : :375.–387.
25.
Mazur
W
,
Lindholm
P
,
Vuorinen
K
, et al.
Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia . Apmis.
2010; ; 118 : :703.–712.
26.
Artaud-Macari
E
,
Goven
D
,
Brayer
S
, et al.
Modulation of fibroblast phenotype in idiopathic pulmonary fibrosis: role of Nrf2 . Am J Respir Crit Care Med.
2011; ; 183 : :A5989..
27.
Marzec
JM
,
Christie
JD
,
Reddy
SP
, et al.
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury . Faseb J.
2007; ; 21 : :2237.–2246.
28.
Kim
SH
,
Choi
GS
,
Ye
YM
, et al.
Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma . Clin Exp Immunol.
2010; ; 160 : :489.–497.
29.
Nichols
DP
,
Ziady
AG
,
Shank
SL
, et al.
The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease . Am J Physiol Lung Cell Mol Physiol.
2009; ; 297 : :L828.–L836.
30.
Rene
C
,
Lopez
E
,
Claustres
M
, et al.
NF-E2-related factor 2, a key inducer of antioxidant defenses, negatively regulates the CFTR transcription . Cell Mol Life Sci.
2010; ; 67 : :2297.–2309.
31.
Ohta
T
,
Iijima
K
,
Miyamoto
M
, et al.
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth . Cancer Res.
2008; ; 68 : :1303.–1309.
32.
Cho
HY
,
Reddy
SP
,
Kleeberger
SR
. Nrf2 defends the lung from oxidative stress . Antioxid Redox Signal.
2006; ; 8 : :76.–87.
33.
Boutten
A
,
Goven
D
,
Artaud-Macari
E
, et al.
NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease . Trends Mol Med.
2011; ; 17 : :363.–371.
34.
Spira
A
,
Beane
JE
,
Shah
V
, et al.
Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer . Nat Med.
2007; ; 13 : :361.–366.
35.
Aoki
Y
,
Hashimoto
AH
,
Amanuma
K
, et al.
Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice . Cancer Res.
2007; ; 67 : :5643.–5648.
36.
Martin-Montalvo
A
,
Villalba
JM
,
Navas
P
,
de Cabo
R
. NRF2, cancer and calorie restriction . Oncogene.
2010; ; 30 : :505.–520.
37.
Shibata
T
,
Ohta
T
,
Tong
KI
, et al.
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy . Proc Natl Acad Sci USA.
2008; ; 105 : :13568.–13573.
38.
Hayes
JD
,
McMahon
M
. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer . Trends Biochem Sci.
2009; ; 34 : :176.–188.
39.
Niso-Santano
M
,
Gonzalez-Polo
RA
,
Bravo-San Pedro
JM
, et al.
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis . Free Radic Biol Med.
2010; ; 48 : :1370.–1381.
40.
Shah
ZA
,
Li
RC
,
Ahmad
AS
, et al.
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway . J Cereb Blood Flow Metab.
2010; ; 30 : :1951.–1961.
41.
Mann
GE
,
Bonacasa
B
,
Ishii
T
,
Siow
RC
. Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones . Curr Opin Pharmacol.
2009; ; 9 : :139.–145.
42.
Yoon
HY
,
Kang
NI
,
Lee
HK
, et al.
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme . Biochem Pharmacol.
2008; ; 75 : :2214.–2223.
43.
Hsu
CL
,
Wu
YL
,
Tang
GJ
, et al.
Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: role of heme oxygenase-1 . Pulm Pharmacol Ther.
2009; ; 22 : :286.–296.
44.
Yang
L
,
Calingasan
NY
,
Thomas
B
, et al.
Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription . PLoS One.
2009; ; 4 : :e5757..
45.
Ichikawa
T
,
Li
J
,
Meyer
CJ
, et al.
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes . PLoS One.
2009; ; 4 : :e8391..
46.
Sussan
TE
,
Rangasamy
T
,
Blake
DJ
, et al.
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice . Proc Natl Acad Sci USA.
2009; ; 106 : :250.–255.